This study aims to compare a new type of knee replacement (Zimmer Persona) with other types already in use (Zimmer Nexgen or Biomet Vanguard), in terms of ROM recovery, gait speed and pain. This case-control not randomized study involved 64 patients operated in Rapallo Hospital between 2013 and 2015. The first assessment carried out at Orthopaedic Department, while the following three performed in the outpatient clinic. Some walking tests were used. Passive ROM in extension and flexion, pain, the use of painkillers and walking aids were used All the patients, after surgery, were submitted to the same physiotherapy treatment in Intensive Rehabilitation Ward in the same hospital. After one year, the two groups improved in all tests, but statistically significant differences in knee extension values and in pain assessed (both to the detriment of the group with the Zimmer Persona System) were observed..