Walking is a complex motor task that requires the proper functioning of numerous neural networks to coordinate peripheral effector muscle structures. Lesions of the central nervous system can compromise the nervous control of locomotion in various ways, affecting the safety due to lack of balance, changes in muscle tone or strength, and alteration of peripheral feedback. A displacement of the center of mass modified the kinetic, kinematic, and spatiotemporal parameters, and the energy expenditure significantly increased. We investigate here the effectiveness of aquatic therapy on walking outcome in some neurological diseases of clinical interest.