Calcific tendinopathy of the rotator cuff is a very common clinical condition caused by the presence of calcium deposits in the tendons of the rotator cuff. The pathogenesis of calcific tendinopathy can be divided into three distinct phases, which reflect the clinical appearance of patients. Pain is the cardinal presenting symptom of this disease. The vast majority of patients are treated conservatively to reduce the pain. The goal of physiotherapy in the management of calcific tendinopathy is to control pain and to maintain joint ROM. There are no studies in the literature regarding the effectiveness of manual therapy in the treatment of this specific clinical condition, but the effectiveness of manual therapy on pain modulation and joint mobility is well known. Therefore, we can use manual techniques of manual therapy in the treatment of calcific tendinopathy dosed in relation to the clinical phase of the disease and the patient’s level of collaboration in order to reduce pain and preserve joint mobility.