The aim of this article was to assess the statistical date reported in the literature regarding manual therapy in patients with carpal tunnel syndrome. Carpal tunnel syndrome is the most common neuropathy of the peripheral nervous system. Its prevalence is 4%-5% in the general population. It is characterized by pain and paresthesia in the distributions of the median nerve. The manual therapy applications could reduce the epineural tethering in the forearm and could improve the nerve gliding in the carpal tunnel during the movement of the wrist, fingers, or elbow. To this end, we searched the current literature for relevant studies, without
over employing a specific methodological criterion for identifying and analyzing the literature. The pain intensity immediately after treatment showed a pooled mean difference of -2.13 with 95% confidence interval (CI) (-2.39, -1.86). Physical function with Boston Carpal Tunnel Syndrome Questionnaire (BCTS-Q) showed a pooled mean difference of -0.89 with 95% CI (-1.08, -0.70) on functional status. Nerve conduction studies showed a mean difference of -1.15 with 95% CI (-1.36, -0.93) on sensory conduction. The manual therapy techniques based on soft tissue and neurodynamic mobilizations, in isolation, is effectiveness on pain, physical function, and nerve conduction studies in patients with carpal tunnel syndrome.